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Inhibition of thrombin generation 12 hours after intake of direct oral anticoagulants.

Michael MetzeChristian PfrepperTristan KlöterStephan StöbeRoland SiegemundThomas SiegemundElvira EdelUlrich LaufsSirak Petros
Published in: Research and practice in thrombosis and haemostasis (2020)
Thrombin generation remains reduced 12 hours after DOAC intake. While thrombin peak is particularly modified by factor Xa inhibitors, all DOACs prolong the lag time and time to thrombin peak. In the setting of bleeding or urgent surgery, the automated thrombin generation assay may assist in decision making and antidote administration.
Keyphrases
  • direct oral anticoagulants
  • venous thromboembolism
  • atrial fibrillation
  • decision making
  • minimally invasive
  • high throughput
  • machine learning
  • weight gain
  • body mass index
  • coronary artery disease