MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro.

Susan Fischer-HuchzermeyerAnna DombrowskiGordon WilkeVerena StahnAnna StreubelVictor Felix MautnerAnja Harder

Published in: PloS one (2017)

We observed therapeutic effects in two of three MPNST cell lines pronounced by combination therapy. These data point to a potentially successful treatment of MPNST by combined application of ATRA and MEK inhibitors such as U0126 or PD0325901.

Keyphrases

combination therapy
peripheral nerve
pi k akt
signaling pathway
electronic health record
lps induced
cell proliferation
big data
immune response
machine learning
inflammatory response
deep learning
toll like receptor