S100A9 Increases IL-6 and RANKL Expressions through MAPKs and STAT3 Signaling Pathways in Osteocyte-Like Cells.

Ryosuke TakagiEijiro SakamotoJun-Ichi KidoYuji InagakiYuka HiroshimaKoji NaruishiHiromichi Yumoto

Published in: BioMed research international (2020)

These results indicated that S100A9 induces IL-6 and RANKL production via engagement with RAGE and TLR4 signalings in osteocytes and suggested that S100A9 may play important roles in the periodontal alveolar bone destruction.

Keyphrases

induced apoptosis
signaling pathway
bone loss
nuclear factor
toll like receptor
pi k akt
inflammatory response
bone mineral density
immune response
cell proliferation
social media
epithelial mesenchymal transition