Neurofilament levels are associated with blood-brain barrier integrity, lymphocyte extravasation, and risk factors following the first demyelinating event in multiple sclerosis.

Tomas UherMason McCombShery GalkinBarbora SrpovaJohanna OechteringChristian BarroMichaela TyblovaNiels BergslandJan KrasenskyMichael DwyerEva Kubala HavrdovaHelena PosovaManuela VaneckovaRobert ZivadinovDana HorakovaJens KuhleMurali Ramanathan

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)

sNfL levels during the first demyelinating event of MS are associated with greater impairment of BBB integrity, immune cell extravasation, and brain lesion activity on MRI.

Keyphrases

blood brain barrier
multiple sclerosis
cerebral ischemia
risk factors
white matter
magnetic resonance imaging
mass spectrometry
ms ms
peripheral blood
subarachnoid hemorrhage