Acquired Factor VII Deficiency Associated With Chronic Myeloid Leukemia Blast Crisis.
Emily B WolfDavid LiAndre J FernandezLindsay B GardnerCandido E RiveraEwa M WysokinskaMarwan E ShaikhHan W TunVivek RoyMuhamad Alhaj MoustafaPublished in: Journal of investigative medicine high impact case reports (2023)
Factor VII (FVII) is an important, vitamin K-dependent clotting factor. Acquired FVII deficiency is a rare entity that is associated with serious bleeding complications. We report a case of acquired FVII deficiency in a patient with recurrent chronic myeloid leukemia in blast crisis who developed bilateral retinal hemorrhages. The coagulopathy was corrected with the initiation of chemotherapy and subsequent reduction in peripheral blast count.