Iron chelation by oral deferoxamine treatment decreased brain iron and iron signaling proteins.

Max A ThorwaldJose A Godoy-LugoNaomi Santa MariaArarat ChakhoyanPeggy O'DayRussell JacobsBerislav ZlokovicCaleb Finch

Published in: bioRxiv : the preprint server for biology (2024)

WT mice respond to DFO with decreased APP, amyloid processing enzymes, and antioxidant repair. Potential DFO treatment for early-stage AD by DFO should consider the benefits of lowered APP and secretase enzymes.

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