Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes.
Mansor FazlianaZubaidah Nor HanipahPublished in: Metabolites (2022)
This review is aimed at synthesizing the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and at the molecular level. We review the hormonal, adipokine, microbiota, microRNA, and metabolomic changes in human and animal models following metabolic surgery for the treatment of obesity and diabetes. The most relevant studies in this area over the past 17 years have been considered for this review. In most cases, metabolic procedures, especially those that include intestinal bypass components, showed the remission of type 2 diabetes. This involves a variety of weight-independent mechanisms to improve glucose homeostasis, improving insulin sensitivity and secretion, gut microbiota, and bile acid cross-talk.
Keyphrases
- type diabetes
- minimally invasive
- coronary artery bypass
- glycemic control
- weight loss
- insulin resistance
- cardiovascular disease
- surgical site infection
- metabolic syndrome
- mass spectrometry
- body mass index
- blood glucose
- coronary artery disease
- polycystic ovary syndrome
- acute coronary syndrome
- skeletal muscle
- induced pluripotent stem cells
- high fat diet induced
- disease activity
- single molecule
- body weight
- replacement therapy