Deep Brain Stimulation of the Nucleus Basalis of Meynert for Parkinson's Disease Dementia: A 36 Months Follow Up Study.
Davide CapponJames GratwickeLudvic ZrinzoHarith AkramJonathan HyamMarwan HarizPatricia LimousinThomas FoltynieMarjan JahanshahiPublished in: Movement disorders clinical practice (2022)
Whether slower progression of cognitive decline in two patients was in any way related to individual variability in responsiveness to NBM-DBS requires confirmation in a larger series including an unoperated PDD control group. Higher accuracy in covertly orienting attention and better sleep quality at baseline were associated with better cognitive outcomes at 36 months assessment. These results require validation in future studies with larger samples.
Keyphrases
- deep brain stimulation
- cognitive decline
- sleep quality
- mild cognitive impairment
- parkinson disease
- end stage renal disease
- obsessive compulsive disorder
- newly diagnosed
- ejection fraction
- chronic kidney disease
- depressive symptoms
- working memory
- cognitive impairment
- type diabetes
- metabolic syndrome
- current status
- skeletal muscle
- insulin resistance
- patient reported