PSPC1 potentiates TGF-β-dependent metastatic dissemination.

Published in: Molecular & cellular oncology (2018)

Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle component 1 (PSPC1) functions as a master activator of metastatic reprogramming by activating epithelial-to-mesenchymal transition (EMT), stemness and TGF-β1 pro-metastatic switch.

Keyphrases

squamous cell carcinoma
small cell lung cancer
epithelial mesenchymal transition
transforming growth factor
stem cells
transcription factor
papillary thyroid
signaling pathway
bioinformatics analysis
genome wide
immune response
young adults
lymph node metastasis