β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer.

Jiali HuRuitao LuYu ZhangWei LiQian HuCuiyu ChenZhaoqian LiuWei ZhangLing ChenRan XuJia LuoHoward L McLeodYijing He

Published in: Cell & bioscience (2021)

In summary, β-blocker pretreatment could improve the propagation and therapeutic efficacy of T1012G in human gastric cancer by regulating STAT3-PKR signaling cascade, even in the presence of type I IFNs. These data support new strategies of improving the efficacy of OVs in gastric cancer.

Keyphrases

endothelial cells
cell proliferation
induced pluripotent stem cells
artificial intelligence
data analysis