Proteomic Correlates and Prognostic Significance of Kidney Injury in Heart Failure With Preserved Ejection Fraction.
Oday SalmanLei ZhaoJordana B CohenMarie-Joe DibJoe David AzzoSushrima GanArthur Mark RichardsBianca PourmussaRobert Neil DoughtyAli JavaheriDouglas L MannErnst R RietzschelManyun ZhaoZhaoqing WangChristina EbertVanessa P M van EmpelKarl KammerhoffJoseph C MaranvilleJoseph GogainJaclyn DennisPeter H SchaferDietmar A SeiffertDavid A GordonFrancisco Ramírez-ValleThomas P CappolaJulio Alonso ChirinosPublished in: Journal of the American Heart Association (2024)
KI is associated with adverse outcomes in HFpEF independent of baseline eGFR. Patients with HFpEF and KI exhibit a plasma proteomic signature indicative of complement activation, inflammation, fibrosis, and impaired cholesterol homeostasis.