SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages.
Ying ZouJiaqi ZhangJiawei XuLanya FuYizhou XuXianghai WangZhenlin LiLixin ZhuHao SunHui ZhengJiasong GuoPublished in: Cell & bioscience (2021)
Our findings indicate that SIRT6 inhibition impairs peripheral nerve repair through suppressing the migration, phagocytosis, and M2 polarization of macrophages. Therefore, SIRT6 may become a favorable therapeutic target for peripheral nerve injury.