Sera with anti-enteric neuronal antibodies from patients with irritable bowel syndrome promote apoptosis in myenteric neurons of guinea pigs and human SH-Sy5Y cells.

Wenjuan FanGuijun FeiXiaoqing LiXiyu WangChaojun HuHaiwei XinXiaohong SunYongzhe LiJackie D WoodXiu Cai Fang

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

The AENA obvious positive rate in patients with IBS was higher than HS, and sera with higher levels of AENA promoted neuronal apoptosis. AENA-mediated neuropathy might exist in a subset of patients with IBS.

Keyphrases

irritable bowel syndrome
cell cycle arrest
cell death
endoplasmic reticulum stress
induced apoptosis
pi k akt
oxidative stress
endothelial cells
spinal cord
cerebral ischemia
brain injury