Ex-situ oxygenated hypothermic machine perfusion in donation after circulatory death heart transplantation following either direct procurement or in-situ normothermic regional perfusion.
Niels MoeslundImran A ErtugrulMichiel A HuFrederik Flyvholm DalsgaardLars Bo IlkjaerPia RyhammerMichael PedersenMichiel E ErasmusHans EiskjaerPublished in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2023)
In DCD HTX, increased biventricular contractility post-HTX was only observed in hearts preserved with HMP. In addition, the need for inotropic support and signs of myocardial damage were lower in the HMP groups. DCD HTX can be successfully performed using DPP followed by preservation with HMP in a preclinical setting.