Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2.
Salwa NaushinViren SardanaRajat UjjainiyaNitin BhathejaRintu KutumAkash Kumar BhaskarShalini PradhanSatyartha PrakashRaju KhanBirendra Singh RawatKarthik Bharadwaj TallapakaMahesh AnumallaGiriraj Ratan ChandakAmit LahiriSusanta KarShrikant Ramesh MulayMadhav Nilakanth MugaleMrigank SrivastavaShaziya KhanAnjali SrivastavaBhawana TomarMurugan VeerapandianGanesh VenkatachalamSelvamani Raja VijayakumarAjay AgarwalDinesh GuptaPrakash M HalamiMuthukumar Serva PeddhaGopinath M SundaramRavindra P VeerannaAnirban PalVinay Kumar AgarwalAnil Ku MauryaRanvijay Kumar SinghAshok Kumar RamanSuresh Kumar AnandasadagopanParimala KaruppananSubramanian VenkatesanHarish Kumar SardanaAnamika KothariRishabh JainAnupama ThakurDevendra Singh PariharAnas SaifiJasleen KaurVirendra KumarAvinash MishraIranna GogeriGeethavani RayasamPraveen SinghRahul ChakrabortyGaura ChaturvediPinreddy KarunakarRohit YadavSunanda SinghmarDayanidhi SinghSharmistha SarkarPurbasha BhattacharyaSundaram AcharyaVandana SinghShweta VermaDrishti SoniSurabhi SethSakshi VashishtSarita ThakranFirdaus FatimaAkash Pratap SinghAkanksha SharmaBabita SharmaManikandan SubramanianYogendra S PadwadVipin HallanVikram PatialDamanpreet SinghNarendra Vijay TripudePartha ChakrabartiSujay Krishna MaityDipyaman GangulyJit SarkarSistla RamakrishnaBalthu Narender KumarKiran A KumarSumit G GandhiPiyush Singh JamwalRekha ChouhanVijay Lakshmi JamwalNitika KapoorDebashish GhoshGhanshyam ThakkarUmakanta SubudhiPradip SenSaumya Ray ChaudhuryRashmi KumarPawan GuptaAmit TuliDeepak SharmaRajesh P RingeAmarnarayan DMahesh J KulkarniDhanasekaran ShanmugamMahesh S DharneSayed G DastagerRakesh JoshiAmita P PatilSachin N MahajanAbujunaid Habib KhanVasudev WaghRakesh Kumar YadavAjinkya KhilariMayuri BhadangeArvindkumar H ChaurasiyaShabda E KulsangeKrishna KhairnarShilpa ParanjapeJatin KalitaNarahari G SastryTridip PhukanPrasenjit MannaWahengbam RomiPankaj BharaliDibyajyoti OzahRavi Kumar SahuElapavalooru Vssk BabuRajeev SukumaranAiswarya R NairPrajeesh Kooloth ValappilAnoop PuthiyamadamAdarsh VelayudhanpillaiKalpana ChodankarSamir DamareYennapu MadhaviVed Varun AggarwalSumit DahiyaAnurag AgrawalDebasis DashShantanu SenguptaPublished in: eLife (2021)
To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were high-exposure work (odds ratio, 95% confidence interval, p value: 2.23, 1.92-2.59, <0.0001), use of public transport (1.79, 1.43-2.24, <0.0001), not smoking (1.52, 1.16-1.99, 0.0257), non-vegetarian diet (1.67, 1.41-1.99, <0.0001), and B blood group (1.36, 1.15-1.61, 0.001).