Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [11C]-(+)-PHNO.

Mark SlifsteinAnissa Abi-DarghamRagy R GirgisRaymond F SuckowThomas B CooperChaitanya R DivgiPierre SokoloffLudovic LerichePatrick CarberryShunichi OyaSimon K JosephMarlène GuiraudAgnès MontagneValérie BrunnerFlorence GaudouxFrançoise Tonner

Published in: Psychopharmacology (2019)

Overall, F17464 was strongly D3-selective in healthy volunteers, a unique profile for an antipsychotic candidate drug.

Keyphrases

computed tomography
positron emission tomography
emergency department
dna binding
transcription factor
binding protein