DNA methylation of skeletal muscle function-related secretary factors identifies FGF2 as a potential biomarker for sarcopenia.

Jia-Wen LiZheng-Kai ShenYu-Shuang LinZhi-Yue WangMei-Lin LiHui-Xian SunQuan WangCan ZhaoJin-Shui XuXiang LuWei Gao

Published in: Journal of cachexia, sarcopenia and muscle (2024)

Our results suggest that lower FGF2_30 methylation is correlated with the risk and severity of sarcopenia in the older adults, indicating that FGF2 methylation serve as a surrogate biomarker for the screening and evaluation of sarcopenia.

Keyphrases

skeletal muscle
dna methylation
genome wide
insulin resistance
gene expression
community dwelling
physical activity
type diabetes
adipose tissue
drug induced