Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes.
Ihsan A ShehadiFatima-Azzahra DelmaniAreej M JaberHana HammadMurad A AlDamenRaed A Al-QawasmehMonther A KhanfarPublished in: Molecules (Basel, Switzerland) (2020)
Four new complexes derived from adamantly containing hydrazone (APH) ligand with Cu(II) (1), Co(II) (2), Ni(II) (3) and Zn(II) (4), have been synthesized and characterized using different physicochemical methods. The structure of the ligand APH and its copper complex 1 have been established by single-crystal X-ray diffraction direct methods, which reveal that complex 1 has distorted square-pyramidal geometry. Complexes 1-4 are screened against seven human cancer cell lines namely, breast cancer cell lines (MCF7, T47D, MDA-MB-231), prostate cancer cell lines (PC3, DU145) and the colorectal cancer cell line Coco-2, for their antiproliferative activities. Complex 1 has shown a promising anticancer activity compared to the other ones. The structural and spectroscopic analysis of APH and its complexes are confirmed by DFT calculations.
Keyphrases
- prostate cancer
- molecular docking
- endothelial cells
- density functional theory
- breast cancer cells
- high resolution
- molecular dynamics
- gene expression
- radical prostatectomy
- genome wide
- heavy metals
- computed tomography
- magnetic resonance
- dna methylation
- cell proliferation
- young adults
- mass spectrometry
- electron microscopy
- cell cycle arrest
- pi k akt