Buxaustroines A-N, a Series of 17(13→18)abeo-Cycloartenol Triterpenoidal Alkaloids from Buxus austro-yunnanensis and Their Cardioprotective Activities.
Zhi-Nan XiangWen-Qin YiYong-Long WangLi-Dong ShaoCheng-Qi ZhangYan YuanJun PanLuo-Sheng WanJia-Chun ChenPublished in: Journal of natural products (2019)
Buxaustroines A-N (1-14), a series of triterpenoidal alkaloids featuring a novel 17(13→18)abeo motif, were obtained from the extract of Buxus austro-yunnanensis. Their structures were assigned based on NMR data analysis and X-ray diffraction crystallography. A putative biosynthetic pathway for one of the alkaloids from a co-isolate 15 is proposed. In the assessment of their bioactivities, some of the compounds displayed protective effects against doxorubicin-induced injury of myocardial cells. Preliminary structure-activity relationship studies of 1-14, which are based on the same skeleton, were conducted.
Keyphrases
- data analysis
- high resolution
- structure activity relationship
- induced apoptosis
- oxidative stress
- cell cycle arrest
- high glucose
- magnetic resonance
- diabetic rats
- drug delivery
- left ventricular
- electron microscopy
- cancer therapy
- endoplasmic reticulum stress
- magnetic resonance imaging
- solid state
- drug induced
- cell death
- heart failure
- endothelial cells
- crystal structure
- atrial fibrillation
- pi k akt