Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling.

Magdalena Banach-OrłowskaRenata WyszyńskaBeata PyrzyńskaMałgorzata MaksymowiczJakub GołąbMarta Miączyńska

Published in: Cell communication and signaling : CCS (2019)

Our results showed that the reduction of the plasma membrane content of cholesterol or its sequestration strongly potentiated signaling outcome initiated by LTβR. Thus, drugs modulating cholesterol levels could potentially improve efficacy of LTβR-based therapies. Video abstract.

Keyphrases

low density lipoprotein
signaling pathway
oxidative stress
lps induced
pi k akt
immune response
inflammatory response
binding protein