Photocatalytic glucose-appended bio-compatible Ir(III) anticancer complexes.
Zilin ZhuLi WeiYidan LaiOliver W L CarterSamya BanerjeePeter J SadlerHuaiyi HuangPublished in: Dalton transactions (Cambridge, England : 2003) (2022)
Rationally-designed glucose-appended Ir(III) photo-catalysts ([Ir( N , C ) 2 ( N , N -Glc)] + , Ir1-Ir3) show visible light-induced catalytic NAD(P)H oxidation in aqueous solution. The highly in vivo biocompatible complex, Ir3, shows lysosome and mitochondria targeting necro-apoptotic photo-cytotoxicity against various cancer cell lines and multicellular spheroids, while remaining non-toxic in the dark.