Efficacy and safety of adjuvant immunoadsorption in pemphigus vulgaris and pemphigus foliaceus (IA-Pem Study): a multicentre randomised controlled trial.

Nina van BeekRüdiger EmingAlexander ReussDetlef ZillikensMiklós SárdyClaudia GüntherDimitra KiritsiSandrine BenoitStefan BeissertRegine GläserHarald GollnickOrsolya N HorváthChristiane PfeifferMartin RöckenFranziska SchauerStephan SchremlKerstin SteinbrinkAlexander ZinkCarmen Schade-BrittingerMichael HertlEnno Schmidt

Published in: The British journal of dermatology (2023)

In this study, adjuvant IA did not show a shorter time to clinical remission but a corticosteroid-sparing effect. In patients with extensive PV/PF, post hoc analysis suggests that adjuvant IA may possibly lead to earlier remission, but potential adverse events must be carefully weighed against the expected benefits.

Keyphrases

early stage
study protocol
clinical trial
disease activity
systemic lupus erythematosus
climate change
human health