PI3Kδ inhibition potentiates glucocorticoids in B-ALL by decreased receptor phosphorylation and enhanced gene regulation.
Jessica A O ZimmermanMimi FangMiles A PufallPublished in: bioRxiv : the preprint server for biology (2023)
Idelalisib potentiates glucocorticoids in B-ALL in part by reducing GR phosphorylation and enhancing gene regulationInhibition of tissue-restricted PI3Kδ likely allows durable potentiation expressly in B-ALL, even as the glucocorticoid is cleared.