Matrix metalloproteinase-11 regulates inverted papilloma epithelial cell migration and invasion.
Kush PanaraTan Li HuiDeepa KeshariCharles Ching Lick TongJames N PalmerNithin D AdappaJennifer E DouglasNoam A CohenMichael A KohanskiPublished in: International forum of allergy & rhinology (2024)
We established an in vitro model to study IP-derived epithelial cells. MMP-11 is uniquely expressed in IP epithelial cultures compared to control epithelial cultures. Inhibition of MMP-11 limits IP epithelial migration and invasion to levels similar to that of normal sinus mucosa. MMP-11 does not appear to have a functional role in normal sinus epithelium, suggesting that MMP-11 has a role in malignant transformation of IP.
Keyphrases