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G9a promotes immune suppression by targeting the Fbxw7/Notch pathway in glioma stem cells.

Yufei CaoBin LiuLize CaiYanyan LiYulun HuangYouxin ZhouXingjian SunWei YangTing Sun
Published in: CNS neuroscience & therapeutics (2023)
G9a promotes stemness characteristics through binding Fbxw7 promotor to inhibit Fbxw7 transcription in GSCs, forming an immunosuppressive TME, which provides novel treatment strategies for targeting GSCs in antitumor immunotherapy.
Keyphrases
  • stem cells
  • epithelial mesenchymal transition
  • transcription factor
  • cell proliferation
  • drug delivery
  • binding protein
  • dna binding