Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization.

Luyao ShenCong WangRan RenXudong LiuDongqin ZhouYu ChenYu ZhouJuan LeiYang XiaoNan ZhangHuakan ZhaoYongsheng Li

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024)

Our study highlights the significance of FGF19-FGFR4 signaling in macrophage polarization and the pathogenesis of IBD, offering a potential new therapeutic target for IBD.

Keyphrases

ulcerative colitis
risk assessment
human health
binding protein