Metabolic phenotyping of acquired ampicillin resistance using microbial volatiles from Escherichia coli cultures.
Breanna DixonWaqar M AhmedAbubaker A MohamedTimothy FeltonStephen J FowlerPublished in: Journal of applied microbiology (2022)
Our findings suggest that VOC profiles may be utilized to differentiate between resistant and susceptible bacteria using just six compounds. Consequently, the development of machine-learning models using VOC signatures shows considerable diagnostic applicability for the rapid and accurate detection of antimicrobial resistance.
Keyphrases
- antimicrobial resistance
- loop mediated isothermal amplification
- machine learning
- escherichia coli
- microbial community
- high throughput
- sensitive detection
- artificial intelligence
- high resolution
- gas chromatography mass spectrometry
- genome wide
- big data
- real time pcr
- label free
- deep learning
- klebsiella pneumoniae
- gene expression
- staphylococcus aureus
- quantum dots
- gas chromatography