The integration of single-cell and bulk RNA-seq atlas reveals ERS-mediated acinar cell damage in acute pancreatitis.

Kaige YangRongli XieGuohui XiaoZhifeng ZhaoMin DingTingyu LinYiu Sing TsangYing ChenDan XuJian Fei

Published in: Journal of translational medicine (2024)

We deciphered the distinct roadmap of acinar cells in the early stage of AP at single-cell level. ERS and ERAD pathways are crucially important for acinar homeostasis and the pathogenesis of AP.

Keyphrases

single cell
rna seq
early stage
induced apoptosis
transcription factor
high throughput
cell cycle arrest
oxidative stress
cell death
endoplasmic reticulum stress
signaling pathway
squamous cell carcinoma
stem cells
bone marrow
cell proliferation
neoadjuvant chemotherapy
mesenchymal stem cells
locally advanced