Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway.

Qiang SongWenjin ZhangDan ShiZhiliang ZhangQiurong ZhaoMengyuan WangMan HuangJuanjuan MengWei CuiXiao-He Luo

Published in: Cancer medicine (2023)

These findings reveal that CB2 mediates BC via the PI3K/Akt/mTOR signaling pathway. CB2 could be a novel target for the diagnosis and treatment of BC.

Keyphrases

signaling pathway
pi k akt
cell cycle arrest
epithelial mesenchymal transition
endothelial cells
induced apoptosis
oxidative stress
cell proliferation
endoplasmic reticulum stress
single cell
transcription factor
gene expression
dna methylation
breast cancer risk