Ryanodine receptor type 1 content decrease-induced endoplasmic reticulum stress is a hallmark of myopathies.

Jeremy VidalEric A FernandezMartin WohlwendPirkka-Pekka LaurilaAndrea Lopez-MejiaJulien OchalaAlexander J LobrinusBengt KayserIsabel C Lopez-MejiaNicolas PlaceNadège Zanou

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Decreased RyR1 is commonly observed in myopathies and associated to ER stress in vitro, in mouse muscle and in human myopathy muscles, suggesting a potent role of RyR1 depletion-induced ER stress in the pathogenesis of myopathies.

Keyphrases

endoplasmic reticulum stress
high glucose
endothelial cells
diabetic rats
induced apoptosis
drug induced
skeletal muscle
late onset
stress induced