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Quantitative analysis of COX-2 promoter methylation in gastric carcinoma.

Ho Goon KimSeong Yeob RyuKyung Hwa LeeJae Hyuk LeeDong Yi Kim
Published in: Annals of surgical treatment and research (2018)
These results demonstrated that COX-2 promoter methylation was significantly higher in tumor tissues, and was an early event for GC, thus, COX-2 gene methylation may be important in the initial development of gastric carcinogenesis. Thus, GCs with methylation in COX-2 may not be good candidates for treatment with COX-2 inhibitors. Furthermore, COX-2 methylation could be a significant prognostic factor predicting a favorable effect on GC patient outcome when downregulated.
Keyphrases
  • dna methylation
  • genome wide
  • gene expression
  • prognostic factors
  • copy number
  • case report