Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload.

Marcel A Vieira-LaraMarleen B DommerholtWenxuan ZhangMaaike BlankestijnJustina C WoltersFentaw AbegazAlbert GerdingYdwine T van der VeenRachel ThomasRonald P van OsDirk-Jan ReijngoudJohan W JonkerJanine K KruitBarbara M Bakker

Published in: BMC biology (2021)

We conclude that intramuscular lipid accumulation and decreased insulin sensitivity are not due to age-related mitochondrial dysfunction or nutritional overload alone, but rather to their combined effects. Moreover, we identify CPT1B as a potential target to counteract age-dependent intramuscular lipid accumulation and thereby IR.

Keyphrases

insulin resistance
adipose tissue
type diabetes
metabolic syndrome
high fat diet
polycystic ovary syndrome
human health
risk assessment
climate change