The combination of stereotactic radiosurgery with immune checkpoint inhibition or targeted therapy in melanoma patients with brain metastases: a retrospective study.
Filipe MartinsLuis SchiappacasseMarc LevivierConstantin TuleascaMichel A CuendetVeronica Aedo-LopezBianca Gautron MouraKrisztian HomicskoAdrienne BettiniGregoire BerthodCamille L GérardAlexandre WickyJean BourhisOlivier MichielinPublished in: Journal of neuro-oncology (2019)
The concurrent administration of anti-PD-1+/-CTLA-4 mAbs with SRS was associated with improved survival in melanoma patients with newly diagnosed BM. In addition to CNS tumor burden, the extension of systemic disease retains its prognostic value in patients treated with SRS. Elevated serum LDH levels are predictors of poor outcome in these patients.