Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.
Vincent BernardAlexander SemaanJonathan HuangF Anthony San LucasFeven C MuluBret M StephensPaola A GuerreroYanqing HuangJun ZhaoNabiollah KamyabiSubrata SenPaul A ScheetCullen M TaniguchiMichael P KimChing-Wei TzengMatthew H KatzAatur D SinghiAnirban MaitraHector A AlvarezPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
This study demonstrates the ability to perform high-resolution profiling of the transcriptomic changes that occur during multistep progression of cystic PDAC precursors to cancer. Notably, single-cell analysis provides an unparalleled insight into both the epithelial and microenvironmental heterogeneities that accompany early cancer pathogenesis and might be a useful substrate to identify targets for cancer interception.See related commentary by Hernandez-Barco et al., p. 2027.