Network Pharmacology Analysis on the Mechanism of Xihuangwan in Treating Rectal Cancer and Radiation Enteritis.
Minghe LvRong DingPeizhen MaYue FengSu ZengYang ZhangWenhao ShenWenhui GuanE XiangyuHongwei ZengJingping YuPublished in: Current pharmaceutical design (2024)
The active ingredients of XHW, mainly including Quercetin, Ellagic acid, and Stigmasterol, might act on common targets of rectal cancer and radiation enteritis, such as PTGS1, NR3C2, IL-6, EGFR, HIF-1A, CASP3, BCL2, ESR1, MYC, and PPARG, and regulate multiple signaling pathways like PI3K-Akt, TNF, and HIF-1 to inhibit tumor proliferation, tumor angiogenesis, inflammatory responses, and oxidative stress, thereby achieving prevention and treatment of radiation enteritis in rectal cancer patients during radiotherapy. It provided an important reference for further elucidating the anti-inflammation and anti-tumor mechanism and clinical application of XHW.
Keyphrases
- rectal cancer
- pi k akt
- signaling pathway
- locally advanced
- oxidative stress
- endothelial cells
- radiation induced
- induced apoptosis
- cell proliferation
- small cell lung cancer
- epithelial mesenchymal transition
- early stage
- rheumatoid arthritis
- radiation therapy
- transcription factor
- epidermal growth factor receptor
- squamous cell carcinoma
- vascular endothelial growth factor
- smoking cessation