Extracorporeal therapy for amlodipine poisoning.
Kollengode RamanathanBishwabikash MohantySimeon TangGraeme MacLarenPublished in: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs (2019)
A young male presented in refractory shock from amlodipine poisoning despite vasopressors, insulin-normoglycemia therapy, calcium gluconate and glucagon. He needed venoarterial ECMO for hemodynamic support and TPE to remove protein-bound amlodipine. The use of extracorporeal membrane oxygenation (ECMO) for cardiotoxic poisoning and Total Plasma Exchange (TPE) in removing drugs has been described in the literature. We report a rare case where both lifesaving extracorporeal therapies were used in a patient with a severe drug overdose. Stabilizing hemodynamics with ECMO combined with TPE for drug removal is a feasible strategy in unstable patients with amlodipine overdose.
Keyphrases
- extracorporeal membrane oxygenation
- hypertensive patients
- acute respiratory distress syndrome
- rare case
- respiratory failure
- blood pressure
- type diabetes
- drug induced
- mechanical ventilation
- early onset
- case report
- intensive care unit
- adverse drug
- binding protein
- small molecule
- glycemic control
- middle aged
- weight loss
- mesenchymal stem cells