Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function.

Chang-Han ChenHung-Wei LinMeng-Fang HuangChi-Wu ChiangKuen-Haur LeeNguyen Thanh PhuongZong-Yan CaiWen-Chang ChangDing-Yen Lin

Published in: BMC molecular and cell biology (2024)

Together, these results demonstrate that sumoylation of SAP130 regulates its biological functions and that FAF1 plays a crucial role in controlling the SUMO-dependent regulation of transcriptional activity and protein stability of SAP130.

Keyphrases

gene expression
transcription factor
protein protein
amino acid
binding protein
heat shock
small molecule