Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring.
Laura ButruilleLucie MarousezCharlène PourpeFrédérik OgerSimon LecoutreDaniel CathelineSolvig GörsCornelia C MetgesCéline GuinezChristine LaboriePhilippe DeruelleJerome EeckhouteChristophe BretonPhilippe LegrandJean LesageDelphine EberléPublished in: International journal of obesity (2005) (2019)
Our data reveal that maternal HF feeding during suckling programs long-term eWAT expansion in part by SCD1 epigenetic reprogramming. This programming events occurred with drastic changes in breast milk FA composition, suggesting that dietary FAs are key metabolic programming factors in the early postnatal period.
Keyphrases
- high fat diet
- insulin resistance
- adipose tissue
- birth weight
- public health
- pregnancy outcomes
- metabolic syndrome
- skeletal muscle
- dna methylation
- electronic health record
- preterm infants
- type diabetes
- gene expression
- weight gain
- big data
- heart failure
- gestational age
- pregnant women
- single cell
- machine learning
- atrial fibrillation
- preterm birth