Proteomic Signature of HIV-Associated Subclinical Left Atrial Remodeling and Incident Heart Failure.
Tess E PetersonVirginia S HahnRuin MoaddelMin ZhuSabina A HaberlenFrank J PalellaMichael PlankeyJoel S BaderJoao Augusto Costa LimaRobert E GersztenJerome I RotterStephen S RichSusan R HeckbertGregory D KirkDamani A PiggottLuigi FerruciJoseph B MargolickTodd T BrownKatherine C WuWendy S PostPublished in: medRxiv : the preprint server for health sciences (2024)
Proteomic signatures that may contribute to HIV-associated LA remodeling were enriched in immune checkpoint proteins, cytokine signaling, and ECM organization. These signatures were also associated with incident HF among older PWOH, suggesting specific markers of chronic immune activation, systemic inflammation, and fibrosis may identify shared pathways in HIV and aging that contribute to risk of HF.