Activation of Opioid Receptors Attenuates Ischemia/Reperfusion Injury in Skeletal Muscle Induced by Tourniquet Placement.

Yue-Xian GuoGui-Ying WangWen-Jie ChengCai-Zhen YanShuang ZhaoZhao LiPeng LiuXiu-Li Wang

Published in: Mediators of inflammation (2021)

Tourniquet-induced acute limb I/R results in morphological and functional impairment in skeletal muscle. Pretreatment with Oxy attenuates skeletal muscle from acute I/R injury through inhibition of TLR4/NF-κB-dependent inflammatory response and protects SIRT1/PGC-1α-dependent mitochondrial function.

Keyphrases

skeletal muscle
inflammatory response
insulin resistance
lps induced
toll like receptor
oxidative stress
lipopolysaccharide induced
signaling pathway
chronic pain
liver failure
immune response
pain management
type diabetes
ischemia reperfusion injury
drug induced
ultrasound guided