2D AuPd alloy nanosheets: one-step synthesis as imaging-guided photonic nano-antibiotics.
Songliang HeGuoshuai ZhuZhencheng SunJidong WangPing HuiPenghe ZhaoWenwen ChenXingyu JiangPublished in: Nanoscale advances (2020)
The complicated synthesis and undesirable biocompatibility of nanomaterials hinder the synergistic photothermal/photodynamic therapy for bacterial infections. Herein, we develop a one-step preparation method of 2D AuPd alloy nanosheets as imaging-guided photonic nano-antibiotics. 2D AuPd alloy nanosheets with an extremely small thickness (∼1.5 nm) exhibit prominent photothermal effects ( η = 76.6%), excellent ROS generation, strong photoacoustic signals and desirable biocompatibility. AuPd nanosheets can eliminate 100% of representative Gram-positive ( Staphylococcus aureus ) and Gram-negative bacteria ( Escherichia coli ) when irradiated using an 808 nm laser at 1 W cm -2 for 5 minutes. After being modified with a bacterial targeting peptide, under the guidance of photoacoustic imaging, AuPd nanosheets achieve promising synergistic photothermal/photodynamic therapeutic efficacy in treating Staphylococcus aureus infected mice. This work expands the biomedical application of 2D noble metal nanomaterials to the field of photonic nano-antibiotics.
Keyphrases
- cancer therapy
- photodynamic therapy
- staphylococcus aureus
- reduced graphene oxide
- quantum dots
- drug delivery
- high resolution
- metal organic framework
- fluorescence imaging
- escherichia coli
- high speed
- highly efficient
- transition metal
- biofilm formation
- gold nanoparticles
- drug release
- dna damage
- cell death
- metabolic syndrome
- mass spectrometry
- cystic fibrosis
- oxidative stress
- candida albicans
- high fat diet induced
- tandem mass spectrometry
- liquid chromatography