Recipient IL-17A polymorphism rs2275913 is associated with acute graft-versus-host disease after single-unit cord blood transplantation.

Takaaki KonumaMegumi Hamatani-AsakuraMaki Monna-OiwaSeiko KatoShohei AndohKazuaki YokoyamaYasuhito NannyaSatoshi Takahashi

Published in: Transplant immunology (2024)

Our data showed recipient IL-17 A polymorphism rs2275913 was associated with the risk of grade II to IV acute GVHD in adults undergoing single-unit CBT. However, the rs2275913 polymorphism in recipients and donors did not affect survival or relapse. Thus, the polymorphism of IL-17 A rs2275913 in recipients might predict the risk of acute GVHD after single-unit CBT.

Keyphrases

liver failure
cord blood
respiratory failure
aortic dissection
drug induced
kidney transplantation
hepatitis b virus
allogeneic hematopoietic stem cell transplantation
free survival
stem cells
machine learning
big data
bone marrow
mechanical ventilation