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Integrated multi-omics analyses and functional validation reveal TTK as a novel EMT activator for endometrial cancer.

Yu MiaoYosuke KonnoBaojin WangLin ZhuTianyue ZhaiKei IhiraNoriko KobayashiHidemichi WatariXin JinJunming YuePeixin DongMingyan Fang
Published in: Journal of translational medicine (2023)
Our findings establish the clinical significance of TTK as a new biomarker for EC and an as-yet-unknown carcinogenic function. This present study proposes that the therapeutic targeting of TTK might provide a viable approach for the treatment of EC.
Keyphrases
  • endometrial cancer
  • single cell
  • epithelial mesenchymal transition
  • nuclear factor
  • genome wide
  • gene expression
  • dna methylation
  • inflammatory response
  • polycyclic aromatic hydrocarbons