Ribonuclease H2 Subunit A Preserves Genomic Integrity and Promotes Prostate Cancer Progression.

Naoki KimuraKen-Ichi TakayamaYuta YamadaHaruki KumeTetsuya FujimuraSatoshi Inouei

Published in: Cancer research communications (2022)

RNASEH2A was demonstrated to be highly upregulated in aggressive prostate cancer to degrade R-loop accumulation and preserve genomic stability for tumor growth, suggesting that RNase H2 activity could be a promising therapeutic target.

Keyphrases

prostate cancer
radical prostatectomy
copy number
transcription factor
gene expression
dna methylation
genome wide
protein kinase