Inflammation and Monocyte Recruitment due to Aging and Mechanical Stretch in Alveolar Epithelium are Inhibited by the Molecular Chaperone 4-phenylbutyrate.
M S ValentineP A LinkJ A HerbertF J Kamga GninzekoM B SchneckK ShankarJ NkwochaA M ReynoldsRebecca L HeisePublished in: Cellular and molecular bioengineering (2018)
Age increases susceptibility to stretch-induced ER stress and downstream inflammatory gene expression in a primary ATII epithelial cell model. Administration of 4PBA attenuated the increased ER stress and proinflammatory responses from stretch and/or age and significantly reduced monocyte migration to ATII conditioned media.