Evaluation of spinal cord protective threshold of serum memantine, an NMDA receptor antagonist, in a rabbit model of paraplegia.

Nirmal PantheeMinoru OnoTakehito YamamotoMasako IkemuraTsuruhito TanakaYoshifumi ItodaHiroshi Suzuki

Published in: Indian journal of thoracic and cardiovascular surgery (2020)

We showed that memantine is protective against SCI at serum levels ≥ 4.5 ng/ml in a rabbit model; thus, it can be a potential adjunct for spinal protection during thoracic/thoracoabdominal aortic surgeries.

Keyphrases

spinal cord
spinal cord injury
neuropathic pain
aortic valve
left ventricular
heart failure
pulmonary arterial hypertension