Caspase-4/11 is critical for angiogenesis by repressing Notch1 signalling via inhibiting γ-secretase activity.

Linlin FanHao LiuGuofu ZhuShekhar SinghZe YuShumin WangHong LuoShiying LiuYawei XuJunbo GeDongyang Jiang Jinjiang Pang

Published in: British journal of pharmacology (2022)

These findings reveal a critical role of CASP4/11 in adult angiogenesis and make this molecule a promising therapeutic target for angiogenesis-related diseases in the future.

Keyphrases

endothelial cells
vascular endothelial growth factor
wound healing
cell proliferation
current status
gene expression
dna methylation