Dose De-escalation of Intrapleural Tissue Plasminogen Activator Therapy for Pleural Infection. The Alteplase Dose Assessment for Pleural Infection Therapy Project.

Natalia D PopowiczOliver BintcliffeDuneesha De FonsekaKevin G BlythNicola A SmithFrancesco PiccoloGeoffrey MartinDonny WongAnthony EdeyNick MaskellYun Chor Gary Lee

Published in: Annals of the American Thoracic Society (2018)

These pilot data suggest that a starting dose of 5 mg of tPA administered intrapleurally twice daily in combination with 5 mg of DNase for the treatment of pleural infection is safe and effective. This regimen should be tested in future randomized controlled trials.

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