HBV suppresses macrophage immune responses by impairing the TCA cycle through the induction of CS/PDHC hyperacetylation.
Jiaxin BeiYe ChenQianbing ZhangXiaobin WangLiteng LinJingjun HuangWensou HuangMingyue CaiWeiguo CaiYongjian GuoKangshun ZhuPublished in: Hepatology communications (2023)
HBV-induced citrate synthase/pyruvate dehydrogenase complex hyperacetylation negatively modulates the innate immune response by impairing the TCA cycle of macrophages. This mechanism represents a potential therapeutic target for controlling HBV infection.