Formation of Platinum Nanocrystals on Silicon Nanotubes and Corresponding Anti-Cancer Activity in Vitro.
Nguyen T LeGiridhar R AkkarajuJeffery L CofferPublished in: ACS applied bio materials (2019)
Biodegradable porous silicon nanotubes (pSiNTs), functionalized with primary amine moieties via the use of 3-aminopropyltriethoxysilane (APTES), is demonstrated as a template for formation of platinum nanocrystals (Pt NCs) (1-3 nm). Transmission electron microscopy-energy dispersive X-ray analysis (TEM-EDX) indicates a relatively high and tunable concentration of Pt uniformly immobilized on a given nanotube (wt % Pt: 20-60%). In vitro viability and cellular uptake studies are consistent with a time-dependent toxicity of Pt NCs-pSiNTs against HeLa cells that is influenced by the degradation kinetics of the pSiNTs; internalization of the composites inside the cells exerts cellular damage in an apoptotic manner, therefore suggesting promising future applications in anticancer treatments.
Keyphrases
- cell cycle arrest
- induced apoptosis
- electron microscopy
- cell death
- oxidative stress
- drug delivery
- ionic liquid
- endoplasmic reticulum stress
- energy transfer
- room temperature
- signaling pathway
- photodynamic therapy
- high resolution
- pi k akt
- quantum dots
- mass spectrometry
- gas chromatography mass spectrometry
- reduced graphene oxide
- light emitting
- metal organic framework